When your waist is bigger than your pants...

To make a papercraft model easier to build, it's best to break it down into sections in the 3D editing stage, rather than handling it as one, big model.

On a model like Homer, it's very easy to see how you could break the model into the shoes, pants, body, arms and head of course.

If one section is smaller than the other one where they meet (like Homer's pants are smaller than his waist) the easiest way to make the connection is to close the ends of each part, so you can easily build the sections seperately later on and then just glue them on top of eachother.